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ProductsBack/AGI-41998 [2377492-26-5]

AGI-41998 [2377492-26-5]

HY-145778
MedChem Express
CAS Number2377492-26-5
DownloadMSDS
Product group Chemicals
Estimated Purity99.94
Molecular Weight505.29
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Overview

  • Supplier
    MedChem Express
  • Product Name
    AGI-41998 [2377492-26-5]
  • Delivery Days Customer
    10
  • CAS Number
    2377492-26-5
  • Certification
    Research Use Only
  • Estimated Purity
    99.94
  • Molecular Formula
    C22H16BrF3N4O2
  • Molecular Weight
    505.29
  • Scientific Description
    AGI-41998 is a potent and orally active inhibitor of methionine adenosyltransferase 2A (MAT2A) that effectively penetrates the blood-brain barrier. AGI-41998 exhibits inhibitory activities against MAT2A and S-adenosyl methionine (SAM) in HCT-116 MTAP-null cells with IC50s of 22 nM and 34 nM. AGI-41998 can significantly inhibit the proliferation of HCT-116 cells and tumor growth. AGI-41998 can be used to study the role of SAM regulation in the central nervous system (CNS) and colon cancer[1].
  • SMILES
    O=C1C(C2=CC=C(Br)C=C2)=C3N=C(NCC(F)(F)F)N=CC3=CN1C4=CC=C(OC)C=C4
  • Storage Instruction
    -20°C
  • UNSPSC
    12131703