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ProductsBack/AGI-43192 [2377491-54-6]

AGI-43192 [2377491-54-6]

HY-145777
MedChem Express
CAS Number2377491-54-6
DownloadMSDS
Product group Chemicals
Estimated Purity99.47
Molecular Weight484.86
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Overview

  • Supplier
    MedChem Express
  • Product Name
    AGI-43192 [2377491-54-6]
  • Delivery Days Customer
    10
  • CAS Number
    2377491-54-6
  • Certification
    Research Use Only
  • Estimated Purity
    99.47
  • Molecular Formula
    C23H16ClF3N6O
  • Molecular Weight
    484.86
  • Scientific Description
    AGI-43192 is a potent and orally active inhibitor of methionine adenosyltransferase 2A (MAT2A) that limitedly penetrates the blood-brain barrier. AGI-43192 exhibits inhibitory activitity against MAT2A and S-adenosyl methionine (SAM) in HCT-116 MTAP-null cells with IC50s of 32 and 14 nM. AGI-43192 can significantly inhibit the proliferation of HCT-116 cells and tumor growth. AGI-43192 can be used to study the role of SAM regulation in the central nervous system (CNS) and colon cancer[1].
  • SMILES
    O=C1C(C2=CC=C(Cl)C=C2)=C3N=C(NCC(F)(F)F)N=CC3=CN1C4=CC5=CN(C)N=C5C=C4
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12131703