IHC-P analysis of human breast carcinoma tissue using GTX22770 AHR antibody [RPT1]. Left : Primary antibody Right : Negative control without primary antibody Antigen retrieval : heat induced antigen retrieval was performed using 10mM sodium citrate (pH6.0) buffer, microwaved for 8-15 minutes Dilution : 1:100
![WB analysis of 20 ug of HepG2, U2OS, and K562 whole cell lysates using GTX22770 AHR antibody [RPT1]. Dilution : 1:1000](https://www.genetex.com/upload/website/prouct_img/normal/GTX22770/GTX22770_1587_WB_w_23060620_783.webp "WB analysis of 20 ug of HepG2, U2OS, and K562 whole cell lysates using GTX22770 AHR antibody [RPT1]. Dilution : 1:1000")
![ICC/IF analysis of NIH-3T3 cells using GTX22770 AHR antibody [RPT1]. Cells were probed without (right) or with(left) an antibody. Green : Primary antibody Blue : Nuclei Red : Actin Fixation : formaldehyde Dilution : 1:200 overnight at 4oC](https://www.genetex.com/upload/website/prouct_img/normal/GTX22770/GTX22770_414_ICC-IF_w_23060620_585.webp "ICC/IF analysis of NIH-3T3 cells using GTX22770 AHR antibody [RPT1]. Cells were probed without (right) or with(left) an antibody. Green : Primary antibody Blue : Nuclei Red : Actin Fixation : formaldehyde Dilution : 1:200 overnight at 4oC")
IHC-P analysis of human breast carcinoma tissue using GTX22770 AHR antibody [RPT1]. Left : Primary antibody Right : Negative control without primary antibody Antigen retrieval : heat induced antigen retrieval was performed using 10mM sodium citrate (pH6.0) buffer, microwaved for 8-15 minutes Dilution : 1:100
AHR antibody [RPT1]
GTX22770
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetAHR
Overview
- SupplierGeneTex
- Product NameAHR antibody [RPT1]
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500 - 1:2000. ICC/IF: 1:100-1:1000. IHC-P: 1:10 - 1:100. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDRPT1
- ConjugateUnconjugated
- Gene ID196
- Target nameAHR
- Target descriptionaryl hydrocarbon receptor
- Target synonymsFVH3, RP85, bHLHe76, aryl hydrocarbon receptor, AH-receptor, ah receptor, aromatic hydrocarbon receptor, class E basic helix-loop-helix protein 76
- HostMouse
- IsotypeIgG1
- Protein IDP35869
- Protein NameAryl hydrocarbon receptor
- Scientific DescriptionThe protein encoded by this gene is a ligand-activated helix-loop-helix transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450. Before ligand binding, the encoded protein is sequestered in the cytoplasm; upon ligand binding, this protein moves to the nucleus and stimulates transcription of target genes. [provided by RefSeq, Sep 2015]
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Shang H, Huang C, Xiao Z, et al. Gut microbiota-derived tryptophan metabolites alleviate liver injury via AhR/Nrf2 activation in pyrrolizidine alkaloids-induced sinusoidal obstruction syndrome. Cell Biosci. 2023,13(1):127. doi: 10.1186/s13578-023-01078-4Read this paper
- Iizuka T, Yin P, Zuberi A, et al. Mono-(2-ethyl-5-hydroxyhexyl) phthalate promotes uterine leiomyoma cell survival through tryptophan-kynurenine-AHR pathway activation. Proc Natl Acad Sci U S A. 2022,119(47):e2208886119. doi: 10.1073/pnas.2208886119Read this paper
- Zhan Y, Zhang Z, Liu Y, et al. NUPR1 contributes to radiation resistance by maintaining ROS homeostasis via AhR/CYP signal axis in hepatocellular carcinoma. BMC Med. 2022,20(1):365. doi: 10.1186/s12916-022-02554-3Read this paper
- Zhong C, Peng L, Tao B, et al. TDO2 and tryptophan metabolites promote kynurenine/AhR signals to facilitate glioma progression and immunosuppression. Am J Cancer Res. 2022,12(6):2558-2575.Read this paper
- Ma X, Jin H, Chu X, et al. The Host CYP1A1-Microbiota Metabolic Axis Promotes Gut Barrier Disruption in Methicillin-Resistant Staphylococcus aureus-Induced Abdominal Sepsis. Front Microbiol. 2022,13:802409. doi: 10.3389/fmicb.2022.802409Read this paper
- Reynolds WJ, Hanson PS, Critchley A, et al. Exposing human primary dermal fibroblasts to particulate matter induces changes associated with skin aging. FASEB J. 2020,34(11):14725-14735. doi: 10.1096/fj.202001357RRead this paper
- Sadik A, Somarribas Patterson LF, Öztürk S, et al. IL4I1 Is a Metabolic Immune Checkpoint that Activates the AHR and Promotes Tumor Progression. Cell. 2020,182(5):1252-1270.e34. doi: 10.1016/j.cell.2020.07.038Read this paper
- Su HH, Lin HT, Suen JL, et al. Aryl hydrocarbon receptor-ligand axis mediates pulmonary fibroblast migration and differentiation through increased arachidonic acid metabolism. Toxicology. 2016,370:116-126. doi: 10.1016/j.tox.2016.09.019Read this paper
- Mariuzzi L, Domenis R, Orsaria M, et al. Functional expression of aryl hydrocarbon receptor on mast cells populating human endometriotic tissues. Lab Invest. 2016,96(9):959-971. doi: 10.1038/labinvest.2016.74Read this paper
- Floreani M, De Martin S, Gabbia D, et al. Severe liver cirrhosis markedly reduces AhR-mediated induction of cytochrome P450 in rats by decreasing the transcription of target genes. PLoS One. 2013,8(4):e61983. doi: 10.1371/journal.pone.0061983Read this paper
Datasheet
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