AIF antibody [N1C1]
GTX113306
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetAIFM1
Overview
- SupplierGeneTex
- Product NameAIF antibody [N1C1]
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID9131
- Target nameAIFM1
- Target descriptionapoptosis inducing factor mitochondria associated 1
- Target synonymsAIF, AUNX1, CMT2D, CMTX4, COWCK, COXPD6, DFNX5, NADMR, NAMSD, PDCD8, SEMDHL, apoptosis-inducing factor 1, mitochondrial, apoptosis-inducing factor, mitochondrion-associated, 1, auditory neuropathy, X-linked recessive 1, programmed cell death 8 (apoptosis-inducing factor), striatal apoptosis-inducing factor, testicular secretory protein Li 4
- HostRabbit
- IsotypeIgG
- Protein IDO95831
- Protein NameApoptosis-inducing factor 1, mitochondrial
- Scientific DescriptionThis gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells that is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it effects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Several alternative transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq]
- ReactivityHuman, Mouse, Rat
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Ma PW, Wang WL, Chen JW, et al. Treatment with the Ferroptosis Inhibitor Ferrostatin-1 Attenuates Noise-Induced Hearing Loss by Suppressing Ferroptosis and Apoptosis. Oxid Med Cell Longev. 2022,2022:3373828. doi: 10.1155/2022/3373828Read this paper
- Geng Q, Li H, Zhang H, et al. Association between Ca(v)3 channel upregulation in spiral ganglion neurons and age-dependent hearing loss. Exp Gerontol. 2021,151:111429. doi: 10.1016/j.exger.2021.111429Read this paper
- Shimada M, Yamashita A, Saito M, et al. The human papillomavirus E6 protein targets apoptosis-inducing factor (AIF) for degradation. Sci Rep. 2020,10(1):14195. doi: 10.1038/s41598-020-71134-3Read this paper
- Murata MM, Kong X, Moncada E, et al. NAD+ consumption by PARP1 in response to DNA damage triggers metabolic shift critical for damaged cell survival. Mol Biol Cell. 2019,30(20):2584-2597. doi: 10.1091/mbc.E18-10-0650Read this paper
- Shen H, Liu W, Geng Q, et al. Age-Dependent Up-Regulation of HCN Channels in Spiral Ganglion Neurons Coincide With Hearing Loss in Mice. Front Aging Neurosci. 2018,10:353. doi: 10.3389/fnagi.2018.00353Read this paper
- Lin SC, Chu PY, Liao WT, et al. Glycyrrhizic acid induces human MDA-MB-231 breast cancer cell death and autophagy via the ROS-mitochondrial pathway. Oncol Rep. 2018,39(2):703-710. doi: 10.3892/or.2017.6123Read this paper
- Chen MF, Huang SJ, Huang CC, et al. Saikosaponin d induces cell death through caspase-3-dependent, caspase-3-independent and mitochondrial pathways in mammalian hepatic stellate cells. BMC Cancer. 2016,16:532. doi: 10.1186/s12885-016-2599-0Read this paper
- Kuo HF, Liu PL, Chong IW, et al. Pigment Epithelium-Derived Factor Mediates Autophagy and Apoptosis in Myocardial Hypoxia/Reoxygenation Injury. PLoS One. 2016,11(5):e0156059. doi: 10.1371/journal.pone.0156059Read this paper
- Ma C, Pan Y, Yang Z, et al. Pre-administration of BAX-inhibiting peptides decrease the loss of the nigral dopaminergic neurons in rats. Life Sci. 2016,144:113-20. doi: 10.1016/j.lfs.2015.11.019Read this paper




![IHC-P analysis of hmuan oophoroma tissue section using GTX00833 AIF antibody [GT1143]. Dlution : 1:100](https://www.genetex.com/upload/website/prouct_img/normal/GTX00833/GTX00833_20191101_AP_003_42_w_23053121_674.webp)


