Bio-Connect

AIF antibody [N1C1]

GTX113306
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetAIFM1
Sign in to order and to see your custom pricing.
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    GeneTex
  • Product Name
    AIF antibody [N1C1]
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID9131
  • Target name
    AIFM1
  • Target description
    apoptosis inducing factor mitochondria associated 1
  • Target synonyms
    AIF, AUNX1, CMT2D, CMTX4, COWCK, COXPD6, DFNX5, NADMR, NAMSD, PDCD8, SEMDHL, apoptosis-inducing factor 1, mitochondrial, apoptosis-inducing factor, mitochondrion-associated, 1, auditory neuropathy, X-linked recessive 1, programmed cell death 8 (apoptosis-inducing factor), striatal apoptosis-inducing factor, testicular secretory protein Li 4
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDO95831
  • Protein Name
    Apoptosis-inducing factor 1, mitochondrial
  • Scientific Description
    This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells that is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it effects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Several alternative transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq]
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Ma PW, Wang WL, Chen JW, et al. Treatment with the Ferroptosis Inhibitor Ferrostatin-1 Attenuates Noise-Induced Hearing Loss by Suppressing Ferroptosis and Apoptosis. Oxid Med Cell Longev. 2022,2022:3373828. doi: 10.1155/2022/3373828
    Read this paper
  • Geng Q, Li H, Zhang H, et al. Association between Ca(v)3 channel upregulation in spiral ganglion neurons and age-dependent hearing loss. Exp Gerontol. 2021,151:111429. doi: 10.1016/j.exger.2021.111429
    Read this paper
  • Shimada M, Yamashita A, Saito M, et al. The human papillomavirus E6 protein targets apoptosis-inducing factor (AIF) for degradation. Sci Rep. 2020,10(1):14195. doi: 10.1038/s41598-020-71134-3
    Read this paper
  • Murata MM, Kong X, Moncada E, et al. NAD+ consumption by PARP1 in response to DNA damage triggers metabolic shift critical for damaged cell survival. Mol Biol Cell. 2019,30(20):2584-2597. doi: 10.1091/mbc.E18-10-0650
    Read this paper
  • Shen H, Liu W, Geng Q, et al. Age-Dependent Up-Regulation of HCN Channels in Spiral Ganglion Neurons Coincide With Hearing Loss in Mice. Front Aging Neurosci. 2018,10:353. doi: 10.3389/fnagi.2018.00353
    Read this paper
  • Lin SC, Chu PY, Liao WT, et al. Glycyrrhizic acid induces human MDA-MB-231 breast cancer cell death and autophagy via the ROS-mitochondrial pathway. Oncol Rep. 2018,39(2):703-710. doi: 10.3892/or.2017.6123
    Read this paper
  • Chen MF, Huang SJ, Huang CC, et al. Saikosaponin d induces cell death through caspase-3-dependent, caspase-3-independent and mitochondrial pathways in mammalian hepatic stellate cells. BMC Cancer. 2016,16:532. doi: 10.1186/s12885-016-2599-0
    Read this paper
  • Kuo HF, Liu PL, Chong IW, et al. Pigment Epithelium-Derived Factor Mediates Autophagy and Apoptosis in Myocardial Hypoxia/Reoxygenation Injury. PLoS One. 2016,11(5):e0156059. doi: 10.1371/journal.pone.0156059
    Read this paper
  • Ma C, Pan Y, Yang Z, et al. Pre-administration of BAX-inhibiting peptides decrease the loss of the nigral dopaminergic neurons in rats. Life Sci. 2016,144:113-20. doi: 10.1016/j.lfs.2015.11.019
    Read this paper