AITRL/TNFSF18, Mouse (HEK293, Fc)

MedChem Express

AITRL/TNFSF18, Mouse (HEK293, Fc)

10

Research Use Only

95.00

Tnfsf18

tumor necrosis factor (ligand) superfamily, member 18

Gi; GITR ligand; Gitrl; glucocorticoid-induced TNF-related ligand; glucocorticoid-induced-tumor necrosis factor receptor ligand; Tnlg2a; tumor necrosis factor ligand 2a; tumor necrosis factor ligand superfamily member 18

Tumor necrosis factor ligand superfamily member 18

AITRL, a type II transmembrane protein, is a ligand for glucocorticoid-induced TNFR-related protein (GITR). When AITRL binds to GITR, GITR can produce costimulatory signals that regulate T-cell proliferation and effector functions. GITR/AITRL interaction plays a role in the pathogenesis of tumor, inflammation, as well as autoimmune diseases[1]. Besides, AITRL plays a role in endothelial cells (EC)-activation and increases STAT-1 phosphorylation and the expression of adhesion molecules (VCAM-1, ICAM-1)[2]. AITRL/TNFSF18 Protein, Mouse (HEK293, Fc) is a recombinant mouse AITRL (T47-S173) with N-terminal hFc tag, which is expressed in HEK293.

-20°C

41116100