AITRL/TNFSF18, Mouse (HEK293, Fc)
HY-P78299
Protein IDQ7TS55
Product group Proteins / Signaling Molecules
Overview
- SupplierMedChem Express
- Product NameAITRL/TNFSF18, Mouse (HEK293, Fc)
- Delivery Days Customer10
- CertificationResearch Use Only
- Estimated Purity95.00
- Protein IDQ7TS55
- Protein NameTumor necrosis factor ligand superfamily member 18
- Scientific DescriptionAITRL, a type II transmembrane protein, is a ligand for glucocorticoid-induced TNFR-related protein (GITR). When AITRL binds to GITR, GITR can produce costimulatory signals that regulate T-cell proliferation and effector functions. GITR/AITRL interaction plays a role in the pathogenesis of tumor, inflammation, as well as autoimmune diseases[1]. Besides, AITRL plays a role in endothelial cells (EC)-activation and increases STAT-1 phosphorylation and the expression of adhesion molecules (VCAM-1, ICAM-1)[2]. AITRL/TNFSF18 Protein, Mouse (HEK293, Fc) is a recombinant mouse AITRL (T47-S173) with N-terminal hFc tag, which is expressed in HEK293.
- Storage Instruction-20°C
- UNSPSC12352202