Bio-Connect

AITRL/TNFSF18, Mouse (HEK293, Fc)

HY-P78299
MedChem Express
Protein IDQ7TS55
Product group Proteins / Signaling Molecules
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Overview

  • Supplier
    MedChem Express
  • Product Name
    AITRL/TNFSF18, Mouse (HEK293, Fc)
  • Delivery Days Customer
    10
  • Certification
    Research Use Only
  • Estimated Purity
    95.00
  • Protein IDQ7TS55
  • Protein Name
    Tumor necrosis factor ligand superfamily member 18
  • Scientific Description
    AITRL, a type II transmembrane protein, is a ligand for glucocorticoid-induced TNFR-related protein (GITR). When AITRL binds to GITR, GITR can produce costimulatory signals that regulate T-cell proliferation and effector functions. GITR/AITRL interaction plays a role in the pathogenesis of tumor, inflammation, as well as autoimmune diseases[1]. Besides, AITRL plays a role in endothelial cells (EC)-activation and increases STAT-1 phosphorylation and the expression of adhesion molecules (VCAM-1, ICAM-1)[2]. AITRL/TNFSF18 Protein, Mouse (HEK293, Fc) is a recombinant mouse AITRL (T47-S173) with N-terminal hFc tag, which is expressed in HEK293.
  • Storage Instruction
    -20°C
  • UNSPSC
    12352202