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AITRL/TNFSF18 Trimer, Human (HEK293, His-Flag)

Name: AITRL/TNFSF18 Trimer, Human (HEK293, His-Flag)
SKU: HY-P78448_M09
Availability: BackOrder

HY-P78448

Protein IDQ9UNG2

Product group Proteins / Signaling Molecules

Overview

Supplier
MedChem Express
Product Name
AITRL/TNFSF18 Trimer, Human (HEK293, His-Flag)
Delivery Days Customer
10
Certification
Research Use Only
Estimated Purity
95.0
Gene ID8995
Target name
TNFSF18
Target description
TNF superfamily member 18
Target synonyms
activation-inducible TNF-related ligand; AITR ligand; AITRL; GITR ligand; GITRL; glucocorticoid-induced TNF-related ligand; glucocorticoid-induced TNFR-related protein ligand; hGITRL; TL6; TNLG2A; tumor necrosis factor (ligand) superfamily, member 18; tumor necrosis factor ligand 2A; tumor necrosis factor ligand superfamily member 18; tumor necrosis factor superfamily member 18
Protein IDQ9UNG2
Protein Name
Tumor necrosis factor ligand superfamily member 18
Scientific Description
AITRL, a type II transmembrane protein, is a ligand for glucocorticoid-induced TNFR-related protein (GITR). When AITRL binds to GITR, GITR can produce costimulatory signals that regulate T-cell proliferation and effector functions. GITR/AITRL interaction plays a role in the pathogenesis of tumor, inflammation, as well as autoimmune diseases[1]. Besides, AITRL plays a role in endothelial cells (EC)-activation and increases STAT-1 phosphorylation and the expression of adhesion molecules (VCAM-1, ICAM-1)[2]. AITRL/TNFSF18 Trimer Protein, Human (HEK293, His-Flag) is a recombinant human AITRL (Q72-S199) trimer with N-terminal His and Flag tag, which is expressed in HEK293.
Storage Instruction
-20°C
UNSPSC
41116100