Bio-Connect

AK-2292

HY-148813
MedChem Express
Estimated Purity99.73
Product group Chemicals
Molecular Weight1070.13
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Overview

  • Supplier
    MedChem Express
  • Product Name
    AK-2292 [2984506-77-4]
  • Delivery Days Customer
    5
  • Certification
    Research Use Only
  • Estimated Purity
    99.73
  • Molecular Formula
    C52H54F2N7O10PS2
  • Molecular Weight
    1070.13
  • Scientific Description
    AK-2292 is a potent and selective STAT5 PROTAC degrader, with a DC50 of 0.10 microM. AK-2292 induces degradation of STAT5A/B proteins in vitro and in vivo. AK-2292 can induce tumor regression in acute myeloid leukemia and chronic myeloid leukemia xenograft mouse models[1][2]. AK-2292 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
  • SMILES
    FC(C1=CC=C2C(C=C(C(N[C@@H](C(C)(C)C)C(N3[C@H](C(N(CCC(N(CCCC#CC4=CC=CC5=C4CN(C(CC6)C(NC6=O)=O)C5=O)C)=O)C7=CC=C(C8=NC=CS8)C=C7)=O)CCC3)=O)=O)S2)=C1)(P(O)(O)=O)F
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12131703