AKB-6899 [1007377-55-0]

TargetMol Chemicals

AKB-6899 [1007377-55-0]

4

1007377-55-0

Research Use Only

AKB-6899

0.9711

C14H11FN2O4

290.25

AKB-6899 is an inhibitor of prolyl hydroxylase domain 3 (PHD3) and increases the soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treated macrophages. AKB-6899 leads to stabilization of HIF-2alpha which induces sVEGFR-1 production from tumor-associated macrophages and decreases tumor growth.

3 years

OC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(F)c1

-20°C

12352200