AKN-028 (TFA) [1175017-91-0]
HY-118304A
CAS Number1175017-91-0
Product group Chemicals
Molecular Weight416.36
Overview
- SupplierMedChem Express
- Product NameAKN-028 (TFA) [1175017-91-0]
- Delivery Days Customer9
- CAS Number1175017-91-0
- CertificationResearch Use Only
- Molecular FormulaC19H15F3N6O2
- Molecular Weight416.36
- Scientific DescriptionAKN-028 TFA, a novel tyrosine kinase (TK) inhibitor, is a potent, orally active FMS-like receptor tyrosine kinase 3 (FLT3) inhibitor with an IC50 value of 6 nM. AKN-028 TFA inhibits FLT3 autophosphorylation. AKN-028 TFA induces dose-dependent cytotoxic response (mean IC50=1 microM). AKN-028 TFA induces apoptosisby activation of caspase 3. AKN-028 TFA can be used in research of acute myeloid leukemia (AML)[1].
- SMILESNC1=NC=C(C2=CC=NC=C2)N=C1NC3=CC4=C(NC=C4)C=C3.O=C(O)C(F)(F)F
- UNSPSC12352200