AKT-IN-28

MedChem Express

AKT-IN-28

999

Research Use Only

C32H28FNO8

573.57

AKT-IN-28 is an Akt allosteric inhibitor, a derivative of Shikonin (HY-N0822). AKT-IN-28 effectively binds to the allosteric site of Akt through hydrophobic and hydrogen interactions with Kd of 2.07 microM. AKT-IN-28 significantly inhibits Akt activity, induces cell apoptosis, arrests cell cycle in G2/M phase, and suppresses proliferation, migration and metabolism of KRAS mutant colorectal cancer cells[1].

OC1=CC=C(O)C2=C1C(C=C(C(OC(CC3=CC=C(NC(COC4=CC=C(F)C=C4)=O)C=C3)=O)C/C=C(C)\C)C2=O)=O

12131703