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AKT peptide

Research Use Only
GTX29041
GeneTex
ApplicationsNeutralisation/Blocking
Product group Proteins / Signaling Molecules
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Overview

  • Supplier
    GeneTex
  • Product Name
    AKT peptide
  • Delivery Days Customer
    9
  • Applications
    Neutralisation/Blocking
  • Certification
    Research Use Only
  • Concentration
    1 mg/ml
  • Scientific Description
    Akt (Protein Kinase B, PKB) is a key regulator of many signal transduction pathways (reviewed in ref 1). Its tight control over cell proliferation and cell viability are manifold; overexpression or inappropriate activation of Akt has been seen in many types of cancer. Akt mediates many of the downstream events of PI 3-kinase (a lipid kinase activated by growth factors, cytokines and insulin). PI 3-kinase recruits Akt to the membrane, where it is activated by PDK1 phosphorylation (reviewed in 2). Once phosphorylated, Akt dissociates from the membrane and phosphorylates targets in the cytoplasm and the cell nucleus. Akt has two main roles: (i) inhibition of apoptosis; (ii) promotion of proliferation.
  • Storage Instruction
    -20°C or -80°C
  • UNSPSC
    12352202