Akt/mTOR-IN-1

MedChem Express

Akt/mTOR-IN-1

5

Research Use Only

C31H21F3N2O3

526.51

Akt/mTOR-IN-1 (Compound 8r) is an AKT/mTOR signaling pathway inhibitor exhibiting an IC50 value of 0.8 microM with anticancer activity. Akt/mTOR-IN-1 can decrease the expression of Caspase 3 and increase the expression of the autophagic protein Cyclin B1, thereby inducing cell autophagy and apoptosis. Akt/mTOR-IN-1 can be used in research related to non-small cell lung cancer (NSCLC)[1].

O=C1NC(C2(O)C=CC(C=C2)=O)=C(C3=CC=C(C(F)(F)F)C=C3)C4=C1N(CC5=CC=CC=C5)C6=C4C=CC=C6

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