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Aldolase B Protein, Human, Recombinant (GST)

Research Use Only
TMPY-02622
TargetMol Chemicals
Product group Molecular Biology
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    Aldolase B Protein, Human, Recombinant (GST)
  • Delivery Days Customer
    16
  • Certification
    Research Use Only
  • Scientific Description
    The aldolase family members involved in metabolism and glycolysis are present in three isoforms: ALDOA, ALDOB, and ALDOC. Aldolases are differentially expressed in human tissues, and aberrant expression has been observed in several human diseases and cancer types. Via GATA6, metastatic cells in the liver upregulate the enzyme aldolase B (ALDOB), which enhances fructose metabolism and provides fuel for major pathways of central carbon metabolism during tumor cell proliferation. Targeting ALDOB or reducing dietary fructose significantly reduces liver metastatic growth but has little effect on the primary tumor. Hereditary fructose intolerance (HFI) is an autosomal recessive disorder caused by aldolase B (ALDOB) deficiency resulting in an inability to metabolize fructose. The toxic accumulation of intermediate fructose-1-phosphate causes multiple metabolic disturbances, including postprandial hypoglycemia, lactic acidosis, electrolyte disturbance, and liver/kidney dysfunction.
  • Storage Instruction
    -20°C
  • UNSPSC
    12352204