Alectinib (Hydrochloride)

MedChem Express

Alectinib (Hydrochloride) [1256589-74-8]

5

1256589-74-8

Research Use Only

99.92

C30H35ClN4O2

519.08

Alectinib Hydrochloride (CH5424802 Hydrochloride; RO5424802 Hydrochloride; AF-802 Hydrochloride) is a potent, selective, and orally available ALK inhibitor with an IC 50 of 1.9 nM and a K d value of 2.4 nM (in an ATP-competitive manner), and also inhibits ALK F1174L and ALK R1275Q with IC 50 s of 1 nM and 3.5 nM, respectively [1] . Alectinib demonstrates effective central nervous system (CNS) penetration [2] .

[H]Cl.N#CC1=CC2=C(C3=C(N2)C(C)(C4=CC(N5CCC(CC5)N6CCOCC6)=C(C=C4C3=O)CC)C)C=C1

2°C to 8°C

12352200