Alisertib sodium [1028486-06-7]

TargetMol Chemicals

Alisertib sodium [1028486-06-7]

86

1028486-06-7

Research Use Only

Alisertib sodium

C27H20ClFN4NaO4

541.92

Alisertib sodium (MLN 8237) is a potent and specific inhibitor (IC50 = 1.2 nM) of Aurora A kinase, an enzyme involved in cell division. By binding to Aurora A kinase, Alisertib sodium disrupts the formation of the mitotic spindle, causing abnormal cell division. At the molecular level, it acts on the AKT/mTOR/AMPK/p38 pathway, leading to the induction of apoptosis and autophagy in leukemic cells, and exhibits significant antitumor activity.

3 years

[Na].COc1cc(Nc2ncc3CN=C(c4cc(Cl)ccc4-c3n2)c2c(F)cccc2OC)ccc1C(O)=O - c:11 -

-20°C

12352200