ALK (Anaplastic Lymphoma Kinase) / CD246(ALK/1031), CF740 conjugate, 0.1mg/mL

Biotium

ALK (Anaplastic Lymphoma Kinase) / CD246(ALK/1031), CF740 conjugate, 0.1mg/mL

16

Western Blot

Research Use Only

Monoclonal

ALK/1031

0.1 mg/ml

Other Conjugate

ALK

ALK receptor tyrosine kinase

ALK1, CD246, NBLST3, ALK tyrosine kinase receptor, CD246 antigen, anaplastic lymphoma receptor tyrosine kinase, mutant anaplastic lymphoma kinase

IgG2b

ALK tyrosine kinase receptor

The wild-type anaplastic lymphoma kinase (ALK) protein is a 200 kDa transmembrane receptor tyrosine kinase. Its expression is restricted to a few scattered cells in the nervous system (some glial cells and neurons, and a few endothelial cells and pericytes). ALK has been found to be rearranged, mutated, or amplified in a series of tumors. The hybrid gene, NPM-ALK, created by the t(2;5)(p23;q35) chromosomal translocation, encodes part of the nucleolar phosphoprotein nucleophosmin (NPM), joined to the entire cytoplasmic portion of ALK. As a consequence, the ALK gene comes under the control of the NPM promoter, which induces a permanent and ubiquitous transcription of the NPM-ALK hybrid gene, resulting in the production of a 80 kDa NPM-ALK chimeric protein. This translocation is found in anaplastic large cell lymphomas (ALCL). Reportedly, expression of ALK indicates a better prognosis. Approximately 5%-10% of non-small cell lung carcinomas also express ALK protein, producing a cytoplasmic staining pattern. This MAb also reacts with blood vessels that serves as an internal positive control. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Animal

2°C to 8°C,RT

41116100