ALK-IN-21 [2901889-01-6]

MedChem Express

ALK-IN-21 [2901889-01-6]

10

2901889-01-6

Research Use Only

C35H45ClN6O6S4

809.48

ALK-IN-21 (Compound B10), a potent ALK inhibitor for ALKG1202R mutation, exhibits remarkable enzymatic inhibitory potency with IC50 values of 4.59 nM, 2.07 nM and 5.95 nM toward ALKWT, ALKL1196M and ALKG1202R, respectively. ALK-IN-21 efficiently inhibits the proliferation of ALK-positive Karpas299 and H2228 cells both with IC50 values of 0.07 microM. ALK-IN-21 can be used for the research of anaplastic large cell lymphoma[1].

CC1=CC(NC2=NC(NC3=C(C=CC=C3)S(=O)(C(C)C)=O)=C(C=N2)Cl)=C(C=C1C4CCN(CC4)C(CSC(N5CCS(=O)(CC5)=O)=S)=O)OC(C)C

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