ALOX5 Polyclonal Antibody

Elabscience

ALOX5 Polyclonal Antibody

12

ImmunoHistoChemistry

ELISA IHC

Research Use Only

Polyclonal

0.7 mg/ml

Unconjugated

ALOX5

arachidonate 5-lipoxygenase

5-LO, 5-LOX, 5LPG, LOG5, polyunsaturated fatty acid 5-lipoxygenase, LOX-5, arachidonic acid 5-lipoxygenase, leukotriene A4 synthase

Rabbit

IgG

Polyunsaturated fatty acid 5-lipoxygenase

This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

-20°C

41116161