alpha 1 Catenin antibody

GeneTex

alpha 1 Catenin antibody

9

WB: 1:500-1:10000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Polyclonal

1.11 mg/ml

Unconjugated

CTNNA1

catenin alpha 1

CAP102, MDBS2, MDPT2, catenin alpha-1, alpha-E-catenin, catenin (cadherin-associated protein), alpha 1, 102kDa, epididymis secretory sperm binding protein, renal carcinoma antigen NY-REN-13

Rabbit

IgG

Catenin alpha-1

Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherence junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.

-20°C or -80°C,2°C to 8°C

12352203