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ProductsBack/alpha1A-AR Degrader 9c [2863635-02-1]

alpha1A-AR Degrader 9c [2863635-02-1]

HY-147100
MedChem Express
CAS Number2863635-02-1
DownloadMSDS
Product group Chemicals
Estimated Purity99.60
Molecular Weight829.82
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Overview

  • Supplier
    MedChem Express
  • Product Name
    alpha1A-AR Degrader 9c [2863635-02-1]
  • Delivery Days Customer
    10
  • CAS Number
    2863635-02-1
  • Certification
    Research Use Only
  • Estimated Purity
    99.60
  • Molecular Formula
    C38H43N11O11
  • Molecular Weight
    829.82
  • Scientific Description
    alpha1A-AR Degrader 9c (compound 9c) is a potent, selective and reversible alpha1A-AR (Adrenergic receptor) PROTAC degrader, with a DC50 of 2.86 microM. alpha1A-AR Degrader 9c induces alpha1A-AR degradation can be attributed to proteasomal degradation. alpha1A-AR Degrader 9c inhibits the proliferation of PC-3 cells, with an IC50 of 6.12 microM. alpha1A-AR Degrader 9c shows antitumor activity, and can be used for prostate cancer research[1].
  • SMILES
    O=C(NC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)COCCOCCOCCN4N=NC(C(N5CCN(C6=NC(N)=C7C=C(OC)C(OC)=CC7=N6)CC5)=O)=C4
  • Storage Instruction
    -20°C
  • UNSPSC
    12131703