Alternariol [641-38-3]

BioViotica

Alternariol [641-38-3]

10

6.1

641-38-3

Research Use Only

>98%

Danger,Excepted quantity

C14H10O5

258.2

Chemical. CAS: 641-38-3. Formula: C14H10O5. MW: 258.2. Isolated from Alternaria sp. Mycotoxin. Phytotoxin. Shows cytotoxic, teratogenic, mutagenic and genotoxic properties by DNA intercalation. Induces several types of DNA damage, including oxidative DNA damage, single-stranded DNA breaks (SSB) and double-strand, through AOH-induced ROS production and interaction with DNA topoisomerase. Inhibits the activity of topoisomerase IIalpha in mammalian cells. Induces cell growth arrest in G2/M phase. GSK-3beta inhibitor (sub-microM IC50 values). Antiviral activity (herpes simplex). Hepatitis C NS3-4A protease inhibitor. Induces cytochrome P450 1A1 expression and apoptosis in mouse hepatoma cells. - Mycotoxin. Phytotoxin. Shows cytotoxic, teratogenic, mutagenic and genotoxic properties by DNA intercalation. Induces several types of DNA damage, including oxidative DNA damage, single-stranded DNA breaks (SSB) and double-strand, through AOH-induced ROS production and interaction with DNA topoisomerase. Inhibits the activity of topoisomerase IIalpha in mammalian cells. Induces cell growth arrest in G2/M phase. GSK-3beta inhibitor (sub-microM IC50 values). Antiviral activity (herpes simplex). Hepatitis C NS3-4A protease inhibitor. Induces cytochrome P450 1A1 expression and apoptosis in mouse hepatoma cells.

OC1=CC(C2=C(C)C=C(O)C=C2O3)=C(C(O)=C1)C3=O

2°C to 8°C

UN 3462

12352200