ALV1 [2438124-79-7]

TargetMol Chemicals

ALV1 [2438124-79-7]

72

Research Use Only

ALV1

C25H23ClN4O5

494.93

ALV1 is a potent degradation agent of Ikaros and Helios, with similar degradation activity against IKZF1/2/3. ALV1 significantly reduced the protein abundance of IKZF1-4, CK1alpha (casein kinase 1alpha, CSNK1A1) and ribosomal protein RPL4, and induced Helios/CRBN dimerization, which promoted IL-2 secretion.

3 years

Cc1ccc(NC(=O)CCc2cccc(NC3=CC(=O)N(C4CCC(=O)NC4=O)C3=O)c2)cc1Cl

-20°C

12352200