AM-1430

Biorbyt

AM-1430

10

Research Use Only

98.00%

C23H19FN8O

442.46

AM-1430 is a potent and selective PI3Kdelta inhibitor. AM-1430 has cellular potency: pAKT IC50 = 0.8 nM; HWB,u (pAKT) IC 50 = 7.7 nM. Rat KLH: IgG ED50 -= 0.016 mg/kg; IhM ED50 = 0.015 mg/kg. Rat PK Clu = 1.7 L/hr/kg.

CNC(C1=C(C2=NC=CC=C2)C([C@H](C)NC3=NC=NC(N)=C3C#N)=NC4=CC=CC(F)=C14)=O

-20°C

12352200