AM-6494 [1874232-80-0]

MedChem Express

AM-6494 [1874232-80-0]

10

1874232-80-0

Research Use Only

C22H21F2N5O3S

473.50

AM-6494 is a potent and orally active BACE1 (efficacious beta-site amyloid precursor protein cleaving enzyme 1) inhibitor (IC50=0.4 nM) with in vivo selectivity over BACE2 (IC50=18.6 nM)[1]. AM-6494 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

O=C(C1=NC=C(OCC#C)N=C1)NC2=CC(F)=C(F)C([C@@]3(C)N=C(N)S[C@@]4(COC)C[C@@]34[H])=C2

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