AM-8508 [1338483-67-2]

TargetMol Chemicals

AM-8508 [1338483-67-2]

72

Research Use Only

AM-8508

C19H15FN8

374.37

AM-8508 is a potent and selective PI3Kdelta inhibitor. AM-8508 showed good cellular potency (in vitro pAKT IC50 = 4.6 nM ). AM-8505 xhibited excellent HWB potency (HWB (pAKT) IC50 = 2.7 nM). AM-8508 inhibit KLH-specific antibodies in animal models, signifying its potential for the treatment of human inflammatory diseases. PI3Kalpha and PI3Kbeta are ubiquitously expressed and play a role in cell growth, division, and survival.

3 years

[C@H](NC=1C(C#N)=C(N)N=CN1)(C)C=2N(C=3C(N2)=CC=C(F)C3)C=4C=CC=NC4

-20°C

12352200