Amcenestrant

MedChem Express

Amcenestrant [2114339-57-8]

9

2114339-57-8

Research Use Only

99.79

C31H30Cl2FNO3

554.48

SAR439859 (compound 43d) is an orally active, non-steroidal, and selective estrogen receptor degrader (SERD). SAR439859 is an effective ER antagonist with ER degradation activity, an EC 50 of 0.2 nM. SAR439859 can show potent anti-tumor effects and limited cross-resistance in ER + breast cancer.

O=C(C1=CC=C(C(C2=CC=C(O[C@@H]3CN(CCCF)CC3)C=C2)=C(C4=CC=C(Cl)C=C4Cl)CCC5)C5=C1)O

-20°C,2°C to 8°C

12352200