AMG-47a

MedChem Express

AMG-47a [882663-88-9]

10

882663-88-9

Research Use Only

99.34

C29H28F3N5O2

535.56

AMG-47a is a potent and orally active lymphocyte-specific protein tyrosine kinase (Lck) inhibitor, with an IC 50 of 0.2 nM. AMG-47a also inhibits VEGF2 , p38alpha , Jak3 and MLR and IL-2 with IC 50 s of 1 nM, 3 nM, 72 nM, 30 nM and 21 nM, respectively. AMG-47a has anti-inflammatory activity [1] .

O=C(NC1=CC=CC(C(F)(F)F)=C1)C2=CC=C(C)C(C3=CC4=CN=C(NCCN5CCOCC5)N=C4C=C3)=C2

-20°C,2°C to 8°C

12352200