AMG 837 (hemicalcium) [1291087-14-3]

MedChem Express

AMG 837 (hemicalcium) [1291087-14-3]

10

1291087-14-3

Research Use Only

C26H21F3O3.1/2Ca

457.48

AMG 837 hemicalcium is a potent, orally bioavailable and partial agonist of GPR40/FFA1. AMG 837 hemicalcium inhibits specific [3H]AMG 837 binding at the human FFA1 receptor with a pIC50 of 8.13. AMG 837 hemicalcium could enhance insulin secretion and lower glucose levels in rodents[1][2][3].

CC#C[C@@H](CC([O-])=O)C1=CC=C(OCC2=CC=CC(C3=CC=C(C=C3)C(F)(F)F)=C2)C=C1.[Ca+2].[1/2]

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