AMG PERK 44

MedChem Express

AMG PERK 44 [1883548-84-2]

10

1883548-84-2

Research Use Only

99.81

C34H29ClN4O2

561.07

AMG PERK 44 is an orally active and highly selective PERK inhibitor with an IC 50 of 6 nM. AMG PERK 44 has 1000-fold and 160-fold selectivity over GCN2 (IC 50 =7300 nM) and B-Raf (IC 50 >1000 nM), respectively. AMG PERK 44 induces autophagy [1] [2] .

O=C1N(C2=CC=CC=C2)N(C)C(C3=CC=CC=C3)=C1C(C4=CC=C(C)C(C5=CC=C6N=C(C)C=CC6=C5)=C4N)=O.[H]Cl

-20°C

12352200