AMG131 (benzenesulfonate) [849738-78-9]

MedChem Express

AMG131 (benzenesulfonate) [849738-78-9]

9

849738-78-9

Research Use Only

C27H18Cl4N2O6S2

672.38

AMG131 (INT131) (benzenesulfonate) is a potent non-thiazolidinedione (TZD) selective peroxisome proliferator-activated receptor gamma modulator (SPPARM). AMG131 (benzenesulfonate) binds to PPARgamma within the same binding pocket as the TZDs, but occupies a unique space in the pocket and contacts the receptor at distinct points from the TZDs. AMG131 (benzenesulfonate) is promising for research of type-2 diabetes mellitus[1][2][3].

O=S(O)(C1=CC=CC=C1)=O.O=S(NC2=CC(Cl)=C(C(Cl)=C2)OC3=CN=C4C=CC=CC4=C3)(C5=CC=C(C=C5Cl)Cl)=O

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