AMG8380

MedChem Express

AMG8380 [1642112-32-0]

10

1642112-32-0

Research Use Only

C25H16ClF2N3O5S

543.93

AMG8380, an orally active and less active enantiomer of AMG8379, can serves as a negative control. AMG8380 inhibits human and mouse voltage-gated sodium channel NaV1.7 with IC 50 s of 0.907 and 0.387 microM, respectively. AMG8380 blocks Tetrodotoxin (TTX)-sensitive native channels with an IC 50 of 2560 nM [1] .

O=S(NC1=NOC=C1)(C2=CC(C=CC(N3C4=CC(F)=C(C=C4OC)C5=CC(Cl)=CC(F)=C5)=O)=C3C=C2)=O.[R]

12352200