Amidate-VC-PAB-MMAF [2202782-90-7]

MedChem Express

Amidate-VC-PAB-MMAF [2202782-90-7]

10

2202782-90-7

Research Use Only

C69H102N11O16P

1372.59

Amidate-VC-PAB-MMAF consists a cleavable ADC linker (Amidate-VC-PAB) and a potent tubulin polymerization inhibitor (MMAF). Amidate-VC-PAB-MMAF can be used in the synthesis of antibody-drug conjugates (ADCs). Amidate-VC-PAB-MMAF reduces off-target cytotoxicity of ADCs[1].

C[C@@H](C(N[C@H](C(O)=O)CC1=CC=CC=C1)=O)[C@H]([C@@](CCC2)([H])N2C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OCC(C=C3)=CC=C3NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(C(C=C4)=CC=C4N[P](OCC)(C#C)=O)=O)=O)=O)=O)=O)=O)=O)OC

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