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Amitriptyline [50-48-6]

Name: Amitriptyline [50-48-6]
SKU: HY-B0527_M09
Availability: BackOrder

HY-B0527

CAS Number50-48-6

Product group Chemicals

Estimated Purity99.94

Molecular Weight277.40

Overview

Supplier
MedChem Express
Product Name
Amitriptyline [50-48-6]
Delivery Days Customer
5
CAS Number
50-48-6
Certification
Research Use Only
Estimated Purity
99.94
Hazard Information
h302-h315-h319-h335,p261-p264-p270-p271-p280-p302+p352-p304+p340-p305+p351+p338-p330-p362+p364-p403+p233-p405-p501
Molecular Formula
C20H23N
Molecular Weight
277.40
Scientific Description
Amitriptyline is an orally active tricyclic antidepressant (TCA). Amitriptyline mainly exerts its antidepressant effect by blocking SERT (Ki = 3.45 nM) and NET (Ki = 13.3 nM), thereby increasing the concentrations of 5-hydroxytryptamine (5-HT) and norepinephrine (NE) in the synaptic cleft. Amitriptyline is also an agonist at alpha2A and TrkA/TrkB receptors, thereby exerting analgesic and neurotrophic activities (inhibiting cell apoptosis). Amitriptyline can reduce inflammation, angiogenesis and fibrosis. Amitriptyline binds to DAT (with Ki = 2.58 microM). Amitriptyline has high affinity for a series of receptors and can antagonize muscarinic cholinergic receptors (M1/M2/M3/M4/M5 receptors) (Ki = 11-24 nM), H1 receptors (Ki = 0.5-1.1 nM), adrenergic alpha1 receptors (Ki = 4.4 nM), etc., resulting in a series of side effects. Amitriptyline can block sodium channels and hERG potassium channel (IC50 = 4.78 microM) and it has cardiotoxicity[1][2][3][4][5].
SMILES
CN(CC/C=C1C2=CC=CC=C2CCC3=C\1C=CC=C3)C
Storage Instruction
2°C to 8°C
UNSPSC
12352200