AMN082 (free base)

MedChem Express

AMN082 (free base) [83027-13-8]

10

83027-13-8

Research Use Only

98.37

C28H28N2

392.54

AMN082 free base, a selective, orally active, and brain penetrant mGluR7 agonist, directly activates receptor signaling via an allosteric site in the transmembrane domain. AMN082 free base potently inhibits cAMP accumulation and stimulates GTPgammaS binding ( EC 50 values, 64-290 nM) at transfected mammalian cells expressing mGluR7. AMN082 free base shows selectivity over other mGluR subtypes and selected ionotropic glutamate receptors. Antidepressant effects [1] [2] .

C(NCCNC(C1=CC=CC=C1)C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4

2°C to 8°C

12352200