Chemical Structure
Amorfrutin A [80489-90-3]
AG-CN2-0462
Overview
- SupplierAdipoGen Life Sciences
- Product NameAmorfrutin A
- Delivery Days Customer10
- CAS Number80489-90-3
- CertificationResearch Use Only
- Estimated Purity>97%
- Molecular FormulaC21H24O4
- Molecular Weight340.4
- Scientific DescriptionAntidiabetic agent. Potent and selective partial agonist of peroxisome proliferator-activated receptor gamma (PPARgamma), a nuclear receptor regulating lipid and glucose metabolism. Has nanomolar binding affinity to PPARgamma and micromolar binding to the isotypes PPARalpha and PPARbeta/delta. Glucose-lowering agent. Improves insulin sensitivity, glucose tolerance and blood lipid variables without increase of fat storage or hepatoxicity. Shows potent PPARgamma-dependent anti-inflammatory activity. Potent NF-kappaB activation inhibitor by the suppression of IkappaBalpha degradation, p65 nuclear translocation and DNA-binding activity. Antimicrobial agent. - Chemical. CAS: 80489-90-3. Formula: C21H24O4. MW: 340.4. Isolated from Amorpha fruticosa. Antidiabetic agent. Potent and selective partial agonist of peroxisome proliferator-activated receptor gamma (PPARgamma), a nuclear receptor regulating lipid and glucose metabolism. Has nanomolar binding affinity to PPARgamma and micromolar binding to the isotypes PPARalpha and PPARbeta/delta. Glucose-lowering agent. Improves insulin sensitivity, glucose tolerance and blood lipid variables without increase of fat storage or hepatoxicity. Shows potent PPARgamma-dependent anti-inflammatory activity. Potent NF-kappaB activation inhibitor by the suppression of IkappaBalpha degradation, p65 nuclear translocation and DNA-binding activity. Antimicrobial agent.
- SMILESCOC1=C(CC=C(C)C)C(O)=C(C(O)=O)C(CCC2=CC=CC=C2)=C1
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC12352200
References
- Amorfrutin A and B, bibenzyl antimicrobial agents from Amorpha fruticosa: L.A. Mitscher, et al.; Phytochemistry 20, 781 (1981)
- Amorfrutins are potent antidiabetic dietary natural products: C. Weidner, et al.; PNAS 109, 7257 (2012)
- Structural characterization of amorfrutins bound to the peroxisome proliferator-activated receptor gamma: J.C. De Groot, et al.; J. Med. Chem. 56, 1535 (2013)
- Amorfrutin A inhibits TNF-alpha-induced NF-kappaB activation and NF-kappaB-regulated target gene products: H. Shi, et al.; Int. Immunopharmacol. 21, 56 (2014)
- Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARgamma): a review: L. Wang, et al.; Biochem. Pharmacol. 92, 73 (2014)
- Amorfrutins Are Natural PPARgamma Agonists with Potent Anti-inflammatory Properties: L. Fuhr, et al.; J. Nat. Prod. 78, 1160 (2015)