Western blot analysis of extracts of SW620 cells using BIN1 Polyclonal Antibody at dilution of 1:1000.
Western blot analysis of extracts of SW620 cells using BIN1 Polyclonal Antibody at dilution of 1:1000.
Amphiphysin II Polyclonal Antibody
E-AB-60447
Product group Antibodies
Overview
- SupplierElabscience
- Product NameAmphiphysin II Polyclonal Antibody
- Delivery Days Customer12
- CertificationResearch Use Only
- Scientific DescriptionThis gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in several transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.
- UNSPSC12352203