Amyloid-Forming peptide GNNQQNY

Biorbyt

Amyloid-Forming peptide GNNQQNY

10

Research Use Only

98.00%

C33H48N12O14

836.81

Amyloid-Forming peptide GNNQQNY, a biologically active heptapeptide derived from the N-terminal prion-determining domain of yeast Sup35, is instrumental in amyloid fibril formation. Its atomic oligomeric structure has been detailed, serving as an excellent model for investigating early-stage aggregation. The peptide can form three stable beta-sheet structures: in-register parallel, off-register parallel, and anti-parallel. Notably, the in-register parallel dimer aligns closely with amyloid beta-sheet architecture, relying on fewer interpeptide hydrogen bonds and emphasizing hydrophobic interactions, which enhances conformational entropy relative to the anti-parallel arrangement.

[C@H](C(N[C@H](C(N[C@@H](CC1=CC=C(O)C=C1)C(O)=O)=O)CC(N)=O)=O)(NC([C@@H](NC([C@@H](NC([C@@H](NC(CN)=O)CC(N)=O)=O)CC(N)=O)=O)CCC(N)=O)=O)CCC(N)=O

-20°C

12352200