Amyloid Precursor C-Terminal Peptide

TargetMol Chemicals

Amyloid Precursor C-Terminal Peptide

9

Research Use Only

Amyloid precursor c-terminal peptide has the amino acid sequence Gly-Tyr-Glu-Asn-Pro-Thr-Tyr-Lys-Phe-Phe-Glu-Gln-Met-Gln-Asn. APP is best known as the precursor molecule whose proteolysis generates beta-amyloid (Abeta), a 37 to 49 amino acid peptide whose amyloid fibrillar form is the primary component of amyloid plaques found in the brains of Alzheimers disease patients. So it is a possible contributor to Alzheimers pathogenesis through MAPKs- and NF-kappaB-dependent astrocytosis.

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