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ProductsBack/Andrastin A [174232-42-9]
Chemical Structure
Chemical Structure
Chemical Structure

Andrastin A [174232-42-9]

Research Use Only
AG-CN2-0144
AdipoGen Life Sciences
CAS Number174232-42-9
DownloadMSDS
Product group Chemicals
Estimated Purity>95%
Molecular Weight486.6
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Andrastin A
  • Delivery Days Customer
    10
  • CAS Number
    174232-42-9
  • Certification
    Research Use Only
  • Estimated Purity
    >95%
  • Hazard Information
    Warning
  • Molecular Formula
    C28H38O7
  • Molecular Weight
    486.6
  • Scientific Description
    Chemical. CAS: 174232-42-9. Formula: C28H38O7. MW: 486.6. Isolated from Aspergillus fumigatus. Mycotoxin. Protein farnesyltransferase (PFTase) inhibitor. Anti-cancer compound. Directly interacts with P-glycoprotein and inhibits the efflux of antitumor agents in drug resistant cells. - Mycotoxin [1, 5, 7, 8]. Protein farnesyltransferase (PFTase) inhibitor [1-3]. Anti-cancer compound [1-3]. Directly interacts with P-glycoprotein and inhibits the efflux of antitumor agents in drug resistant cells [4, 6].
  • SMILES
    [H]C(=O)[C@@]12CC[C@H](OC(C)=O)C(C)(C)[C@@]1([H])CC[C@@]1(C)[C@@]2([H])C=C(C)[C@@]2(C)C(=O)C(C)=C(O)[C@@]12C(=O)OC
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

References

  • Andrastins A-C, new protein farnesyltransferase inhibitors produced by Penicillium sp. FO-3929. I. Producing strain, fermentation, isolation, and biological activities: S. Omura, et al.; J. Antibiot. 49, 414 (1996)
  • Andrastins A-C, new protein farnesyltransferase inhibitors produced by Penicillium sp. FO-3929. II. Structure and biosynthesis: R. Uchida, et al.; J. Antibiot. 49, 414 (1996)
  • Andrastins A-C, New Protein Farnesyltransferase Inhibitors, Produced by Penicillium sp. FO-3929: K. Shiomi, et al.; THL 37, 1265 (1996)
  • Enhancement of drug accumulation by andrastin A produced by Penicillium sp. FO-3929 in vincristine-resistant KB cells: M.C. Rho, et al.; J. Antibiot. 51, 68 (1998)
  • Andrastins A-D, Penicillium roqueforti Metabolites consistently produced in blue-mold-ripened cheese: K.F. Nielsen, et al.; J. Agric. Food Chem. 53, 2908 (2005)
  • Andrastin A and barceloneic acid metabolites, protein farnesyl transferase inhibitors from Penicillium albocoremium: chemotaxonomic significance and pathological implications: D.P. Overy, et al.; Mycol. Res. 109, 1243 (2005)
  • Proteolytic activity, mycotoxins and andrastin A in Penicillium roqueforti strains isolated from Cabrales, Valdeon and Bejes; Tresviso local varieties of blue-veined cheeses: M.A. Fernandez-Bodega, et al.; Int. J. Food Microbiol. 136, 18 (2009)
  • In vitro cytotoxicity of fungi spoiling maize silage: R.R. Rasmussen, et al.; Food Chem. Tox. 49, 31 (2011)