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ProductsBack/Androgen receptor antagonist 5 [2586195-28-8]

Androgen receptor antagonist 5 [2586195-28-8]

HY-146494
MedChem Express
CAS Number2586195-28-8
Product group Chemicals
Molecular Weight493.43
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Overview

  • Supplier
    MedChem Express
  • Product Name
    Androgen receptor antagonist 5 [2586195-28-8]
  • Delivery Days Customer
    10
  • CAS Number
    2586195-28-8
  • Certification
    Research Use Only
  • Molecular Formula
    C21H15F4N5O3S
  • Molecular Weight
    493.43
  • Scientific Description
    Androgen receptor antagonist 5 (compound 42f) is a potent androgen receptor (AR) antagonist with an IC50 value of 6.17 microM. Androgen receptor antagonist 5 can effectively impair AR nuclear translocation, reducing the levels of nuclear AR, and disrupts AR-mediated gene regulation. Androgen receptor antagonist 5 has antiproliferative activity against LNCaP and exhibits antitumor activity in LNCaP xenograft tumor mice model. Androgen receptor antagonist 5 can be used for researching prostate cancer[1].
  • SMILES
    CCOC(NC1=CC2=C(CC3C(N(C(N3C2)=S)C4=CC(C(F)(F)F)=C(N=C4)C#N)=O)C=C1F)=O
  • UNSPSC
    12131703

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