ANI-7 [931417-26-4]

MedChem Express

ANI-7 [931417-26-4]

10

931417-26-4

Research Use Only

99.01

C13H8Cl2N2

263.12

ANI-7 is an activator of aryl hydrocarbon receptor (AhR) pathway. ANI-7 inhibits the growth of multiple cancer cells, and potently and selectively inhibits the growth of MCF-7 breast cancer cells with a GI50 of 0.56 microM. ANI-7 induces CYP1-metabolizing mono-oxygenases by activating AhR pathway, and also induces DNA damage, checkpoint Kinase 2 (Chk2) activation, S-phase cell cycle arrest, and cell death in sensitive breast cancer cell lines[1][2][3].

ClC1=CC(/C(C#N)=C/C2=CC=CN2)=CC=C1Cl

-20°C,2°C to 8°C

12352200