Antalarmin (hydrochloride)

MedChem Express

Antalarmin (hydrochloride) [220953-69-5]

5

220953-69-5

Research Use Only

99.87

C24H35ClN4

415.01

Antalarmin (hydrochloride) is an oral active non-peptide corticotropin-releasing hormone receptor 1 (CRHR1) antagonist with a K i of 1 nM. Antalarmin hydrochloride suppresses CRH-induced ACTH secretion and blocks CRH and novelty induced anxiety-like behavior in animal models. Antalarmin hydrochloride produces anti-inflammatory effects in arthritis models, and suppresses stress-induced gastric ulceration related to irritable bowel syndrome [1] [2] [3] .

CC1=C(N2C(C)=C(C)C3=C(N(CCCC)CC)N=C(C)N=C32)C(C)=CC(C)=C1.[H]Cl

-20°C

12352200