Anti-14-3-3 Antibody [JJ083-6]

HUABIO

Anti-14-3-3 Antibody [JJ083-6]

7

Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IHC-P

Research Use Only

Monoclonal

JJ083-6

1 mg/ml

Unconjugated

YWHAB

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta

GW128, HEL-S-1, HS1, KCIP-1, YWHAA, 14-3-3 protein beta/alpha, 14-3-3 alpha, epididymis secretory protein Li 1, protein 1054, protein kinase C inhibitor protein-1, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, alpha polypeptide, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide

Rabbit

IgG

14-3-3 protein beta/alpha

14-3-3 proteins are a family of conserved regulatory molecules that are expressed in all eukaryotic cells. 14-3-3 proteins have the ability to bind a multitude of functionally diverse signaling proteins, including kinases, phosphatases, and transmembrane receptors. More than 200 signaling proteins have been reported as 14-3-3 ligands. 14-3-3 proteins play an isoform-specific role in class switch recombination. They are believed to interact with the protein Activation-Induced (Cytidine) Deaminase in mediating class switch recombination. Phosphorylation of Cdc25C by CDS1 and CHEK1 creates a binding site for the 14-3-3 family of phosphoserine binding proteins. Binding of 14-3-3 has little effect on Cdc25C activity, and it is believed that 14-3-3 regulates Cdc25C by sequestering it to the cytoplasm, thereby preventing the interactions with CycB-Cdk1 that are localized to the nucleus at the G2/M transition.

Human, Mouse

Human,Mouse

Rat

-20°C,2°C to 8°C

41116161