Anti-14-3-3 gamma Antibody [SD20-65]

HUABIO

Anti-14-3-3 gamma Antibody [SD20-65]

7

Flow Cytometry, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,FC

Research Use Only

Monoclonal

SD20-65

1 mg/ml

Unconjugated

YWHAG

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma

14-3-3GAMMA, DEE56, EIEE56, PPP1R170, 14-3-3 protein gamma, KCIP-1, protein kinase C inhibitor protein 1, protein phosphatase 1, regulatory subunit 170, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide

Rabbit

IgG

14-3-3 protein gamma

14-3-3 proteins regulate many cellular processes relevant to cancer biology, notably apoptosis, mitogenic signaling and cell-cycle checkpoints. Seven isoforms comprise this family of signaling intermediates, denoted 14-3-3 b, g, e, z, h, q and s. 14-3-3 proteins form dimers that present two binding sites for ligand proteins, thereby bringing together two proteins that may not otherwise associate. These ligands largely share a 14-3-3 consensus binding motif and exhibit serine/threonine phosphorylation. 14-3-3 proteins function in broad regulation of these ligand proteins; by cytoplasmic sequestration, occupation of interaction domains and import/export sequences, prevention of degradation, activation/repression of enzymatic activity, and facilitation of protein modification. Loss of expression contributes to a vast array of pathogenic cellular activities.

Human

Human

Mouse,Rat

-20°C,2°C to 8°C

41116161