Anti-2-Hydroxyisobutyryllysine Antibody Conjugated Agarose Beads

PTM BIO

Anti-2-Hydroxyisobutyryllysine Antibody Conjugated Agarose Beads

5

With a mixture of high-quality rabbit- and mouse-derived anti-crotonyllysine antibodies cross-linked, this Anti-Phosphorylatedtyrosine Antibody Conjugated Agarose Beads present extraordinary capability to specifically capture peptides/proteins bearing crotonyllysine residues but do not cross-react with the peptides/proteins bearing structurally similar acetyllysine residues. This product has been well utilized to affinity purify peptides for global proteomic screening of lysine crotonylation.

IAP

Antibody

Research Use Only

Mix

Agarose

IgG

Histones are subjected to a variety of enzyme catalyzed modifications, including acetylation, methylation, ubiquitylation, etc. 2-Hydroxyisobutyrylation of lysine is a newly identified reversible modification controlling chromosome structure and gene transcription. The reversible lysine 2-hydroxyisobutyrylation has been well demonstrated in eukaryotic histones from worm to human. The unique structure and genomic localization of histone lysine 2-hydroxyisobutyrylation suggest that it is mechanistically and functionally different from histone lysine acetylation.

Stable for 12 months from date of receipt.

All Species

All

Store at -20°C. Avoid freeze/thaw cycles.

12352203