Anti-24P4C12 proteins [Ha5-1(5)2.1]

Absolute Antibody

Anti-24P4C12 proteins [Ha5-1(5)2.1]

9

This antibody specifically binds to recombinant 24P4C12 expressing cells (PC3-24P4C12) and multiple cancer cell lines expressing 24P4C12.

This antibody was capable of binding cells expressing 24P4C12 proteins on their surface in a flow cytometric assay. This antibody can be used in the development of an antibody-drug conjugate for targeted delivery of toxins to cancerous cells. The cytotoxicity of Ha5-1(5)2.1-vcMMAE antibody-drug conjugates was evaluated in PC3 cells engineered to express 24P4C12 and it was reported that it can selectively deliver a cytotoxic drug to 24P4C12 expressing cells leading to their killing. Ha5-1(5)2.1vcMMAE also inhibited the growth of subcutaneous and orthotopically established human androgen-independent prostate cancer xenograft in SCID mice (US8309093).

Flow Cytometry

Research Use Only

Monoclonal

Ha5-1(5)2.1

Human

IgG1

This is a reformatted human IgG1 Fc Silent™ antibody, based on the original human IgG2 format, created for improved compatibility with existing reagents, assays and techniques.

Human

-20°C,2°C to 8°C

12352203