Anti-5 Lipoxygenase Antibody

HUABIO

Anti-5 Lipoxygenase Antibody

7

Western Blot

WB

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

ALOX5

arachidonate 5-lipoxygenase

5-LO, 5-LOX, 5LPG, LOG5, polyunsaturated fatty acid 5-lipoxygenase, LOX-5, arachidonic acid 5-lipoxygenase, leukotriene A4 synthase

Rabbit

IgG

Polyunsaturated fatty acid 5-lipoxygenase

5-lipoxygenase (5-LO) is expressed primarily in polymorphonuclear leukocytes, macrophages, and mast cells. 5-LO performs the first two catalytic reactions in the biosynthesis of leukotrienes, lipid metabolites that induce contractions of airway smooth muscle and increase vascular permeability during anaphylaxis. The cellular localization of 5-LO varies between cell types. In activated blood polymorphonuclear leukocytes 5-LO undergoes calcium dependent translocation from the cytosol to the nuclear envelope. In alveolar macrophages, the majority of 5-LO is localized in the nucleus and, upon activation of these cells, intranuclear 5-LO binds to the nuclear membrane. This intracellular shuttling of 5-LO is dependent on the association with various signaling molecules, phosphorylation and the presence of a distinct

Human

Human

Mouse,Rat

-20°C,2°C to 8°C

41116161