Anti-58K Golgi protein Antibody [JF099-5]

HUABIO

Anti-58K Golgi protein Antibody [JF099-5]

7

Flow Cytometry, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IHC-P,FC

Research Use Only

Monoclonal

JF099-5

1 mg/ml

Unconjugated

FTCD

formimidoyltransferase cyclodeaminase

LCHC1, formimidoyltransferase-cyclodeaminase, formiminotransferase-cyclodeaminase

Rabbit

IgG

Formimidoyltransferase-cyclodeaminase

58K protein antibodies are excellent for use as markers for the Golgi complex. The 58K protein has been identified as being FTCD, a bifunctional enzyme that channels 1-carbon units from formiminoglutamate, a metabolite of the histidine degradation pathway, to the folate pool. Defects in FTCD are the cause of glutamate formiminotransferase deficiency [also known as formiminoglutamicaciduria (FIGLU-uria)], an autosomal recessive disorder. Features of a severe phenotype include elevated levels of formiminoglutamate (FIGLU) in the urine in response to histidine administration, megaloblastic anemia and mental retardation. Features of a mild phenotype include high urinary excretion of FIGLU in the absence of histidine administration, mild developmental delay and no hematological abnormalities.

Human

Human

-20°C,2°C to 8°C

41116161