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ProductsBack/anti-8-Hydroxy-2-deoxyguanosine [8-OHdG], mAb (N45.1)
Immunohistochemical staining of epidermis from hairless mouse by chronic UVB irradiation after 4 weeks of treatment using anti-8-OHdG, mAb (N45.1).
Immunohistochemical staining of epidermis from hairless mouse by chronic UVB irradiation after 4 weeks of treatment using anti-8-OHdG, mAb (N45.1).
Immunohistochemical staining of epidermis from hairless mouse by chronic UVB irradiation after 4 weeks of treatment using anti-8-OHdG, mAb (N45.1).

anti-8-Hydroxy-2-deoxyguanosine [8-OHdG], mAb (N45.1)

Research Use Only
JAI-MOG-020P
JaICA
ApplicationsELISA, ImmunoHistoChemistry
DownloadDatasheet
Product group Antibodies
ReactivityAll Species
Price on request
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More than 130 suppliers
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Overview

  • Supplier
    JaICA
  • Product Name
    anti-8-Hydroxy-2-deoxyguanosine [8-OHdG], mAb (N45.1)
  • Delivery Days Customer
    10
  • Antibody Specificity
    Recognizes 8-OHdG. Does not cross-react with 19 analogues of 8-OHdG (guanosine (G), 7-methylG, 6-SHG, 8-bromoG, dA, dC, dT, dI, dU, dG, O6-methyldG, 8-OHdA, guanine (Gua), O6-methylGua, 8-OHGua, uric acid, urea, creatine, creatinine). Minimal cross-reacti
  • Applications
    ELISA, ImmunoHistoChemistry
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    N45.1
  • Formulation
    Liquid
  • Host
    Mouse
  • Isotype
    IgG1
  • Scientific Description
    8-hydroxy-2-deoxyguanosine (8-OHdG) is a modified base that occurs in DNA due to attack by hydroxyl radicals (incl. singlet oxygen and direct photodynamic action) that are formed as byproducts and intermediates of aerobic metabolism and during oxidative stress. There is increasing evidence to support the involvement of free radical reactions in the damage of biomolecules that eventually lead to several diseases in humans, such as atherosclerosis, cerebral and heart ischemia-reperfusion injury, cancer, rheumatoid arthritis, inflammation, diabetes, aging, and neurodegenerative conditions, such as Alzheimers disease. 8-OHdG is popular as a sensitive, stable and integral marker of oxidative damage in cellular DNA and can be detected in tissue, serum, urine and other biomaterials. - Monoclonal Antibody. Recognizes 8-OHdG. Does not cross-react with 19 analogues of 8-OHdG (guanosine (G), 7-methylG, 6-SHG, 8-bromoG, dA, dC, dT, dI, dU, dG, O6-methyldG, 8-OHdA, guanine (Gua), O6-methylGua, 8-OHGua, uric acid, urea, creatine, creatinine). Minimal cross-reactivity with 8-sulfhydrylG and 8-OHG (less than 1%). Lyophilized. Contains 10mM PBS, pH7.4 containing 1.0% BSA. 8-hydroxy-2-deoxyguanosine (8-OHdG) is a modified base that occurs in DNA due to attack by hydroxyl radicals (incl. singlet oxygen and direct photodynamic action) that are formed as byproducts and intermediates of aerobic metabolism and during oxidative stress. There is increasing evidence to support the involvement of free radical reactions in the damage of biomolecules that eventually lead to several diseases in humans, such as atherosclerosis, cerebral and heart ischemia-reperfusion injury, cancer, rheumatoid arthritis, inflammation, diabetes, aging, and neurodegenerative conditions, such as Alzheimers disease. 8-OHdG is popular as a sensitive, stable and integral marker of oxidative damage in cellular DNA and can be detected in tissue, serum, urine and other biomaterials.
  • Reactivity
    All Species
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352203