Anti-ABL2 Antibody [JF0951]

HUABIO

Anti-ABL2 Antibody [JF0951]

7

Flow Cytometry, Western Blot

WB,FC

Research Use Only

Monoclonal

JF0951

1 mg/ml

Unconjugated

ABL2

ABL proto-oncogene 2, non-receptor tyrosine kinase

ABLL, ARG, tyrosine-protein kinase ABL2, Abelson tyrosine-protein kinase 2, abelson-related gene protein, c-abl oncogene 2, non-receptor tyrosine kinase, tyrosine-protein kinase ARG, v-abl Abelson murine leukemia viral oncogene homolog 2

Rabbit

IgG

Tyrosine-protein kinase ABL2

The Abl oncogene was initially identified as the viral transforming gene of Abelson murine leukemia virus (A-MuLV). The major translational product of c-Abl has been identified as a protein with tyrosine kinase activity and an SH2 domain. The Abl oncogene is implicated in several human leukemias including chronic myelocytic leukemia (CML), in which it undergoes a (9;22) chromosomal translocation and produces the Philadelphia (Ph1) chromosome. The molecular consequence of this translocation is the generation of a chimeric Bcr/c-Abl mRNA encoding activated Abl protein tyrosine kinase. The related protein tyrosine kinase Arg, also designated Abl2, contains an SH2 and an SH3 domain. Arg has been shown to interact with and to phosphorylate c-Crk.

Human, Rat

Human,Rat

Mouse

-20°C,2°C to 8°C

41116161